There are nights when you want a dinner that feels indulgent, comforting, and full of flavor without spending hours in the kitchen. That’s exactly where this creamy Cajun chicken spaghetti with garlic mozzarella sauce shines. It’s rich and velvety, gently spicy, and deeply satisfying, the kind of meal that makes everyone pause after the first bite just to appreciate how good it is.

This dish brings together the bold warmth of Cajun seasoning with the mellow richness of a garlic-infused mozzarella cream sauce. The chicken is seasoned generously, pan-seared until juicy and lightly crisp on the outside, then nestled into silky strands of spaghetti that soak up every bit of that creamy sauce. It’s comfort food with personality—cozy enough for a family dinner, yet flavorful enough to feel restaurant-worthy.

What makes this pasta especially lovable is the balance. Cajun seasoning adds heat and depth, but the cream, butter, and cheese smooth everything out, creating a sauce that’s rich without being overwhelming. Garlic ties it all together, giving the dish that familiar, savory aroma that fills the kitchen and draws everyone to the table.

This recipe is perfect for busy weeknights when you want something special, but it’s also impressive enough for casual entertaining. Pair it with a simple salad or garlic bread, and you’ve got a meal that feels complete, comforting, and a little bit indulgent in the best possible way.

Ingredients:

12 ounces spaghetti
1 pound boneless skinless chicken breasts, sliced
2 tablespoons Cajun seasoning (adjust to taste)
2 tablespoons olive oil
2 tablespoons butter
4 cloves garlic, minced
2 tablespoons all-purpose flour
2 cups heavy cream
1 cup milk
1 1/2 cups shredded mozzarella cheese
1/2 cup grated Parmesan cheese
Salt and black pepper, to taste
Red pepper flakes (optional)
Fresh parsley, chopped (for garnish)

Instructions:

Bring a large pot of salted water to a boil and cook spaghetti according to package instructions until al dente. Reserve 1/2 cup of pasta water, then drain and set aside.
Season the sliced chicken evenly with Cajun seasoning.
Heat olive oil in a large skillet over medium-high heat. Add the chicken and cook for 4–5 minutes per side until cooked through and lightly browned. Remove chicken from the skillet and set aside.
Reduce heat to medium and add butter to the same skillet. Once melted, stir in the minced garlic and cook for about 30 seconds until fragrant.
Sprinkle flour over the garlic butter mixture and whisk constantly for 1 minute to form a light roux.
Slowly whisk in the heavy cream and milk, stirring continuously until smooth.
Simmer the sauce for 3–5 minutes until slightly thickened.
Stir in mozzarella and Parmesan cheese a handful at a time until melted and smooth.
Season the sauce with salt, black pepper, and optional red pepper flakes to taste.
Add the cooked spaghetti and reserved pasta water as needed to loosen the sauce.
Return the chicken to the skillet and toss everything together until well coated and heated through.
Garnish with fresh parsley and serve immediately.

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Creamy spaghetti tossed with Cajun-spiced chicken and a rich garlic mozzarella sauce.

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Prep Time 15

Cook Time 25

Total Time 40

Servings: 4 servings

Course: Dinner

Cuisine: American, Cajun

Calories: 680

Ingredients Equipment Method Notes

Ingredients

Pasta

12 oz spaghetti
1 lb chicken breast sliced
2 tbsp Cajun seasoning
2 tbsp butter
4 cloves garlic minced
2 cups heavy cream
1 1/2 cups mozzarella cheese shredded
1/2 cup Parmesan cheese grated

Equipment

Large pot
Large skillet
Whisk

Method

Cook spaghetti until al dente and reserve pasta water.
Season and cook chicken until browned and cooked through.
Prepare garlic cream sauce with butter, flour, cream, and cheese.
Toss spaghetti and chicken with sauce until well coated.

Notes

Use reserved pasta water to adjust sauce consistency.

Tips & Tricks

Use freshly grated cheese for the smoothest sauce.
Adjust Cajun seasoning depending on your spice tolerance.
Reserve pasta water—it helps create a silky, restaurant-style sauce.

Variations

Add sautéed bell peppers or mushrooms for extra texture.
Swap spaghetti for fettuccine or penne.
Use shrimp instead of chicken for a Cajun seafood twist.

Serving Suggestions
Serve with garlic bread, a crisp Caesar salad, or roasted vegetables to balance the richness of the sauce.

Storage Information
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop with a splash of milk or cream.

FAQ
Can I make this less spicy? Yes, reduce the Cajun seasoning or use a mild blend.
Can I use pre-cooked chicken? Yes, add it during the final step just to warm through.

History / Fun Facts
Cajun cuisine originates from Louisiana and is known for its bold spices and comforting dishes. This pasta is a modern fusion, blending Cajun flavors with classic creamy Italian-style sauces.

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce – Bold, Cozy, and Irresistibly Creamy